This site is intended for US patients and caregivers.

Welcome to the FOTIVDA Patient Page

FOTIVDA is a prescription medicine used to treat adults with advanced kidney cancer (advanced renal cell carcinoma or RCC) that has been treated with 2 or more prior medicines and has come back or did not respond to treatment.

Learn more about treatment with FOTIVDA

Download Patient Information

AVEO ACE is a comprehensive program dedicated to providing personalized support to patients and their loved ones throughout the FOTIVDA treatment journey.

At AVEO ACE, we are dedicated to helping you understand the programs and services available to you.

Once you and your healthcare professional have decided that FOTIVDA is right for you, an AVEO ACE Program Specialist is available to:

  • Explain your insurance coverage for FOTIVDA
  • Connect you to resources to help you access your FOTIVDA treatment
  • Provide ongoing education and support to assist during your treatment journey

Discover the services available to help you through the AVEO ACE program:

Insurance coverage support

Insurance Coverage Support

We know how difficult it can be to understand your health insurance coverage. AVEO ACE Program Specialists are here to help you better understand your insurance coverage for FOTIVDA and access therapy.

An AVEO ACE Program Specialist is available to:

  • Work with your insurance company to conduct benefits investigations and provide coverage information to you and your healthcare professionals
  • Help you access FOTIVDA treatment if there are unexpected insurance coverage delays or interruptions
Financial assistance

Financial Assistance

We care about helping you access your FOTIVDA treatment. AVEO ACE Program Specialists can help explore financial support options that may lower your out-of-pocket costs for FOTIVDA. If eligible, you may qualify for the:

AVEO ACE Co-pay Assistance Program

  • Qualify for co-pay assistance and pay as little as $0 for your FOTIVDA through the AVEO ACE Co-pay Assistance Program. Annual limits of $40,000 apply

Eligibility requirements

A patient must:

  • Be a resident of the US or US Territory
  • Have a commercial (private) insurance plan
  • Not be enrolled in any government-funded insurance programs (Medicare, Medicaid, etc)

Other eligibility requirements and restrictions apply. AVEO Oncology reserves the right to rescind, revoke, amend, or terminate this offer or the program in its entirety at any time.

How to Apply

AVEO ACE Patient Assistance Program

Get FOTIVDA at no cost to you through the AVEO ACE Patient Assistance Program.

Eligibility requirements

A patient must:

  • Be a resident of the US or US Territory
  • Be uninsured or underinsured
  • Meet certain income and financial requirements

Other eligibility requirements and restrictions apply.

How to Apply

OR

Download and print the AVEO ACE Enrollment Form to bring to your next doctor’s appointment. Your healthcare professional will need to complete the “Prescriber Information” section, and you will both need to sign the form. Then, your healthcare professional will submit it (along with copies of your prescription insurance cards) for approval.

Once the AVEO ACE Enrollment Form is received, an AVEO ACE Program Specialist will follow up with you and your healthcare professional regarding next steps within 24 hours.

Ongoing education and support

Ongoing Education and Support

Since it is important to take your FOTIVDA medication as prescribed, we have designed a unique and personalized nurse support program that may help you stay on track with your FOTIVDA treatment.

When you join the AVEO ACE Patient Support Program, a specially trained Oncology Nurse Specialist will be available to:

  • Provide general education on FOTIVDA treatment and what to expect while on treatment
  • Provide resources to help you and your loved ones to understand and manage potential emotions experienced during the treatment journey

Patient support and education does not include medical advice. Your healthcare professional should always be your source for information about your condition and treatment.

To learn more, please

Call 1-833-FOTIVDA

(1-833-368-4832)

Monday through Friday,
8 AM-8 PM ET.

OR

Enroll online

OR

Download and print

the AVEO ACE enrollment form

and fax the completed form
to 1-888-920-2830.

You can also download these AVEO ACE resources:

The AVEO ACE brochure

has information on access and financial support.

The Caregiver Tips brochure

provides helpful resources.

DISCLAIMER:

AVEO ACE makes no representation or guarantee concerning reimbursement or coverage for any service or item. Information provided through the AVEO ACE program does not constitute medical or legal advice and is not intended to be a substitute for a consultation with a licensed healthcare professional, legal counsel, or applicable third-party payer(s). AVEO ACE reserves the right to modify the program at any time without notice.

INDICATIONS AND IMPORTANT SAFETY INFORMATION

FOTIVDA® (tivozanib) is a prescription medicine used to treat adults with advanced kidney cancer (advanced renal cell carcinoma or RCC) that has been treated with 2 or more prior medicines and has come back or did not respond to treatment.

It is not known if FOTIVDA is safe and effective in children.

Possible serious side effects can occur with FOTIVDA. Call or see your healthcare provider right away if you develop:

High blood pressure (hypertension). High blood pressure may be severe, including a sudden, severe increase in your blood pressure (hypertensive crisis) that can lead to death. Your healthcare provider should check your blood pressure after 2 weeks and at least monthly, and may prescribe medicine to treat high blood pressure. You should check your blood pressure regularly and tell your healthcare provider if you have increased blood pressure or experience confusion, headaches, dizziness, chest pain, or shortness of breath.

Heart failure. Heart failure may be serious and sometimes lead to death. Your healthcare provider should check for symptoms of heart failure regularly, such as shortness of breath or swelling of your ankles.

Heart attack and blood clots in your veins or arteries. Blood clots may be serious and sometimes lead to death. Tell your healthcare provider or get emergency medical help right away if you have:

  • new chest pain or pressure
  • numbness or weakness on one side of your body
  • pain in your arms, back, neck or jaw
  • trouble talking
  • shortness of breath
  • sudden severe headache
  • vision changes
  • swelling in the arms or legs

Bleeding problems. Bleeding may be serious and sometimes lead to death. Report or get medical help right away if you have:

  • unusual bleeding from the gums
  • red or black stools (looks like tar)
  • menstrual bleeding or vaginal bleeding that is heavier
  • than normal
  • bruises that happen without a known cause or get larger
  • headaches, feeling dizzy or weak
  • bleeding that is severe or you cannot control
  • coughing up blood or blood clots
  • pink or brown urine
  • vomiting blood or your vomit looks like “coffee grounds”
  • unexpected pain, swelling, or joint pain

Protein in your urine. Your healthcare provider should check your urine for protein before and during treatment.

Thyroid gland problems. Your healthcare provider should do blood tests to check your thyroid gland function before and during your treatment, and may prescribe medicine if you develop thyroid gland problems.

Risk of wound-healing problems. Wounds may not heal properly during treatment. Tell your healthcare provider if you plan to have surgery before starting or during treatment, including dental surgery.

  • You should stop taking FOTIVDA at least 24 days before planned surgery.
  • Your healthcare provider should tell you when you may start taking FOTIVDA again after surgery.

Reversible Posterior Leukoencephalopathy Syndrome (RPLS). RPLS is a condition that can happen. Tell your healthcare provider right away if you have headaches, seizures, confusion, blindness or changes in vision, or difficulty thinking.

Allergic reactions to tartrazine (FD&C Yellow No. 5). FOTIVDA contains a dye called FD&C Yellow No. 5 (tartrazine) that may cause allergic-type reactions, including bronchial asthma, in certain people. This occurs most often in people who also are allergic to aspirin.

The most common side effects of FOTIVDA include:

  • tiredness
  • diarrhea
  • decreased appetite
  • nausea
  • hoarseness
  • low levels of thyroid hormones
  • cough
  • mouth sores
  • decreased blood levels of salt
  • (sodium) and phosphate
  • increased levels of lipase in the
  • blood

Other side effects include vomiting and weakness or lack of energy. FOTIVDA may cause fertility problems in males and females, which may affect your ability to have a child.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with FOTIVDA if you have certain side effects.

These are not all of the possible side effects of FOTIVDA.

Before taking FOTIVDA, tell your healthcare provider about all your medical conditions, including if you:

  • have high blood pressure.
  • have a history of heart failure.
  • have a history of blood clots in your veins or arteries (types of blood vessels), including stroke, heart attack, or change in vision.
  • have bleeding problems.
  • have thyroid problems.
  • have liver problems.
  • have an unhealed wound.
  • plan to have surgery or have had recent surgery, including dental surgery. You should stop taking FOTIVDA at least 24
  • days before planned surgery.
  • are allergic to FD&C Yellow No.5 (tartrazine) or aspirin.
  • are pregnant or plan to become pregnant. FOTIVDA can harm your unborn baby. If you are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment.
    • Use effective birth control (contraception) during treatment and for 1 month after your last dose.
    • Talk to your healthcare provider about birth control methods that may be right for you.
    • Tell your healthcare provider right away if you become pregnant or think you might be pregnant.

Tell your healthcare provider about all the medicine you take and any new medicine, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking FOTIVDA with certain other medicines may affect how FOTIVDA works.

Please see the Patient Information in the full Prescribing Information for FOTIVDA® (tivozanib).